Microangiopathies are diseases affecting small blood vessels — usually capillaries — and are most common in diabetes patients, usually referred to as diabetic microvascular complications.1

Such microvascular complications can severely damage the eyes (retinopathy), kidneys (nephropathy), and nerves (neuropathy):

Diabetic Retinopathy is a microvascular complication of diabetes, and its prevalence increases with the duration of the disease. It is associated with diabetic macular oedema, considered the principal cause of vision loss in working-age diabetic patients, regardless of gender. 1

Diabetic Nephropathy — or diabetic kidney disease — is another microvascular complication of diabetes, and again its prevalence increases with the duration of the disease. Associated with the chronic deterioration of kidney function characterized by protein loss in the urine, it is the leading cause of end-stage kidney disease. 2’3

Diabetic Peripheral Neuropathy — the most common microvascular complication of diabetes — is also more frequent in long-term diabetic patients. Associated with limb and foot disorders, it is the main cause of disability due to foot ulceration and amputation, gait disturbance, and fall-related injury.4

References:

  1. Vujosevic S, Aldington SJ, Silva P, et al. Screening for diabetic retinopathy: new perspectives and challenges. Lancet Diabetes Endocrinol 2020; 8:337.
  2. Schoenfeld ER, Greene JM, Wu SY, Leske MC. Patterns of adherence to diabetes vision care guidelines: baseline findings from the Diabetic Retinopathy Awareness Program. Ophthalmology 2001; 108:563.
  3. Olivarius Nde F, Andreasen AH, Keiding N, Mogensen CE. Epidemiology of renal involvement in newly-diagnosed middle-aged and elderly diabetic patients. Cross-sectional data from the population-based study “Diabetes Care in General Practice”, Denmark. Diabetologia 1993; 36:1007.
  4. Di Vincenzo A, Bettini S, Russo L, et al. Renal structure in type 2 diabetes: facts and misconceptions. J Nephrol 2020; 33:901.
  5. Pop-Busui R, Boulton AJ, Feldman EL, et al. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care 2017; 40:136.